Adj. Associate Professor of Medicine – University of Pennsylvania
Translational Researcher, Biorhythms, Science Educator
Over the past 20 years, I conducted investigator-initiated deep phenotyping studies in volunteers and patients in the areas of pain, inflammation, and atherosclerosis to elucidate molecular mechanisms and drug action of pain relivers (opioids, cyclooxygenase-2 (COX-2) inhibitors) and dietary supplements (fish oil).
More recently, I shifted my focus to understand how time-specific changes of molecular mechanisms drive health and disease. In a collaborative approach, we integrate multiomics (genes, proteins, metabolites, lipids, microbiota, etc.) and phenomics (cognitive function, blood pressure, muscle strength, physical activity, social interaction, personality traits, etc.) to characterize the human chronobiome (time-specific phenotypes) and its modulation by age, sex, and disease. Our goal is to develop time-informed therapeutic strategies for the clinical care of patient populations.
I am passionate to share my knowledge and experiences with the next generation of translational scientists. Each year, I mentor undergraduate students to navigate their research experience through our Translational Research Immersion Program (TRIP). An artist-in-residency program complements this as a public engagement initiative.
My career started in Germany, where I graduated as MD from the University Medical Center, Johannes Gutenberg-University, Mainz and completed my post-doctoral fellowship at the Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt am Main. Currently, I am the Robert L. McNeil Jr. Fellow in Translational Medicine and Therapeutics and an Adjunct Associate Professor in the Department of Medicine at the Perelman School of Medicine, University of Pennsylvania here in Philadelphia, PA.